io8 



Scientific Proceedings (99). 



In two similar experiments with blood-infiltrated wound pockets, 

 in which solutions of chinosol grs. vi to the ounce in combina- 

 tion with 0.6 per cent, and 0.85 per cent, sodium chloride respect- 

 ively, were used, each of the wounds thus treated exhibited an 

 area of dark gray staining of its fatty interior, due to a change 

 produced in the infiltrated corpuscles in the course of from 15 to 

 30 minutes by the action of the chinosol, and both of the wounds 

 suppurated, pure staphylococcus aureus having been found in the 

 pus from each, while the control wounds also infiltrated with 

 blood, both united by primary union. These results led to a 

 study of the action in vitro of solutions of chinosol, and of chinosol 

 and salt, on washed blood corpuscles. In this connection, it is of 

 interest that two sterile blood-infiltrated wound pockets in the sub- 

 cutaneous tissue of a dog, treated with 2 per cent, chinosol in 

 combination with salt, with resulting areas of dark gray and gray- 

 black staining, following primary suture, united by primary union. 

 With the use of the first-aid solution (chinosol grs. iv = 5 i and 

 0.85 per cent, sodium chloride), in experimental wounds into which 

 blood had flowed, a smoky yellow color and occasionally a light 

 grayish tinge have been noted, usually affecting the loose con- 

 nective tissue joining together the superficial and deep layers of 

 the superficial fascia, which at the same time has become the seat 

 of an oedema resulting from an infiltration of it by the solution. 

 In fresh traumatic wounds, staining of the tissues attendant upon 

 the use of the first-aid solution, has, in a limited experience, not 

 been a feature. 



These experiments have shown that the production in fresh 

 wound pockets uncontaminated with blood, of immunity to scien- 

 tific infection with a large number of virulent Staphylococci aurei, 

 by the use of chinosol with iso- and slightly hypo-tonic salt and 

 once by the use of 2 per cent, chinosol alone, has been accomplished 

 in a majority of the twelve instances in which it was attempted, 

 which furnishes proof of the disinfectant action of chinosol on 

 vitalized tissues. The practical application of this knowledge 

 would be to the first-aid treatment of wounds. Thus it would 

 seem that, if fresh traumatic wounds could, within the first few 

 hours of their receipt, at a time when, as Carrel and Dehelly 

 have shown, bacterial growth has hardly begun, have their 



