Chinosol and Salt. 



109 



open lymphatics blocked with a solution of chinosol and iso- 

 tonic salt, comparable to the lymphatic block with the disin- 

 fectant solution preceding the scientific infection with a large 

 number of virulent bacteria in the dog's wounds, that im- 

 munity of these wounds, at least to the ordinary pus germs, in the 

 presence of a but comparatively trivial amount of infection at 

 this early period, could similarly be expected. The lymphatic 

 block of a fresh traumatic wound with chinosol and salt should 

 be superficial, since in the animal experiments an extensive infil- 

 tration of the solution into the lymphatics opening into a wound, 

 following scientific infection of the latter, seemed many times to 

 have been the probable cause of extending the infection to a dis- 

 tance from the site of its implantation. Although blood infiltra- 

 tion associated with the use of the chinosol-salt solution as de- 

 scribed, might be incompatible with the production of immunity 

 against a severe scientific infection in an experimental wound 

 closed by primary suture, yet this same condition would not neces- 

 sarily be incompatible with producing a lymphatic block against 

 the invasion of the tissues by bacteria or with arresting bacterial 

 growth, in a traumatic wound treated open by the introduction into 

 it of gauze packing saturated with the disinfectant solution, es- 

 pecially when the latter is introduced early before the bacteria 

 have begun to multiply greatly. 



Twenty-four grains of chinosol in solution have been infiltrated 

 into the lymphatics of a sterile, fresh wound in the back of a dog 

 weighing 8 kilos, with primary union and without complication. 



Miss W. Carey Noble, of the research laboratory of the New 

 York Board of Health, has made very careful bacteriological 

 tests in vitro with chinosol, which virtually confirm the tests of the 

 Council on Pharmacy and Chemistry 1 of the American Medical 

 Association. 



Dr. Alexander O. Gettler, pathological chemist to Bellevue 

 Hospital and to the City of New York, has done important work 

 on the chemistry of chinosol to incorporate in this report. 



Mr. Pro. V Prewitt, instructor in physiology at the New York 

 University and Bellevue Hospital Medical College, has done a 



1 Report on Chinosol of Council on Pharmacy and Chemistry, American Medi- 

 cal Association, Journ. A. M. A., 1910, LIV, p. 1801; editorial p. 1790. 



