138 



Scientific Proceedings (ioo). 



"peptone" rabbit (1,730 gms.) received only 100 c.c. of water 

 (at 41 0 C.). The dextrose rabbit exhibited a loss of 0.6° C. in 

 one half hour, the control rabbit no loss of temperature. 



It is concluded that dextrose given by mouth under suitable 

 conditions exhibits a decided antipyretic action, due to an increase 

 in the heat elimination. The inference that the carbohydrate 

 metabolism may play an important role in the action of anti- 

 pyretic substances is being submitted to experimental inquiry. 



77 (1452) 



Concerning the effect of prostate feeding on tadpoles. 

 By David I. Macht. 



[From the Johns Hopkins University, Baltimore, Md.] 



Gudernatsch was the first to call attention to the remarkable 

 influence of the feeding of thyroid and thymus glands on frogs' 

 larvae. That observer noted that the thyroid causes a dwarfing 

 or shrinkage of the growth and size of tadpoles, and at the same 

 time very rapidly hastens their metamorphosis into frogs, while 

 the thymus, on the other hand, causes giant tadpoles but inhibits 

 their metamorphosis. Gudernatsch and other observers have 

 also studied the effect of feeding of other organs and glands on the 

 development of frogs' larvae. As far as the present author has 

 been able to ascertain, however, no experiments concerning the 

 feeding of prostate gland to tadpoles are on record. The present 

 author, in connection with a physiological and pharmacological 

 study of prostatic extracts, conducted a series of experiments in 

 feeding tadpoles with desiccated prostatic substance (Armour). 

 The results are so interesting that it is deemed desirable to make 

 a preliminary announcement on the subject in this place. 



Prostate gland was fed to tadpoles of several species of frogs 

 and it was noted that like the thyroid, the feeding of prostate 

 substance tended to hasten the transformation of the larvae into 

 frogs. Such an effect was occasionally noted after administration 

 of the gland substance for three or four days, and generally was 

 distinctly noticeable after a period of from ten to fourteen days. 



