Simplified Food Supply. 9 



in the output of creatine, creatinine and total nitrogen, when these 

 animals were compared with controls similarly treated, but fed 

 soluble starch alone or combined with maltose or lactose in amounts 

 equivalent to the salep administered. There was a faint tendency 

 for creatine and total nitrogen to fall in the starch period, but the 

 results cannot be considered conclusive. 



Salep resembles inulin in its ease of acid hydrolysis, its re- 

 sistance to digestive enzymes, and its failure to form sugar in the 

 diabetic organism. It is not so fermentable as inulin. 



4 (1464) 



Growth and reproduction upon simplified food supply. 

 By H. C. Sherman, M. E. Rouse, B. Allen and E. Woods. 



[From the Laboratory of Food Chemistry ', Columbia University.] 



Rats were fed rations consisting of white bread (made without 

 milk or butter) either alone or with only one other article of food. 

 Later, ground whole wheat was substituted for white bread in 

 several cases. 



In preliminary experiments with animals placed upon the 

 experimental rations at the time of weaning, bread alone resulted 

 in cessation of growth at once and death after about six weeks. 

 With bread and meat there was some growth at first, but the 

 survival period was only slightly longer than with bread alone; 

 with bread and apple there was no growth, but the survival period 

 was considerably longer; with bread and turnip there was con- 

 tinuous slow growth; with bread and milk there was continuous 

 growth at a normal rate. In this case the bread and milk ration 

 consisted of equal weights of fresh bread and market milk, making 

 a food mixture in which the white bread furnished four fifths and 

 the milk one fifth of the total calories. On this ration young 

 rats of both sexes (taken at weaning time from mothers which were 

 receiving mixed food) made normal growth and the males were 

 capable of normal reproduction but the females usually failed to 

 breed and none of them raised any young. 



On a ration containing the same proportion of milk (about 



