22 



Scientific Proceedings (ioi). 



respiratory rate of twenty- two and a minute volume of ten liters 

 while breathing room air. During an experiment in which air con- 

 taining 1 1.4 per cent. C0 2 was inspired for a period of six minutes, 

 the respiratory rate remained at twenty- two and the minute 

 volume increased to only fourteen liters. At this high concentra- 

 tion of inspired CO2 the patient complained of a little dizziness and 

 nausea which disappeared when he was allowed to breath room 

 air for a few minutes. 



In an attempt to explain the unusual tolerance to C0 2 in the 

 inspired air shown by the type of case described, the C0 2 content 

 of the arterial and venous plasma of three patients have been de- 

 termined and found to be consistently above normal as indicated 

 by the data in the accompanying table. 



Table. 



The Total Carbonate Content of the Arterial and Venous Plasma in Three 

 Patients with Chronic Pulmonary Emphysema. 

 CO2 reduced to o°-76o mm. in 100 c.c. plasma. 



Arterial 



Venous 



Arterial 



Venous 



c.c. 



c.c. 



c.c. 



c.c. 



76.I 



82.7 



80.2 



88.4 



72.4 



78.4 



70.2 



76.4 



71.0 



76.O 



74-5 



80.2 



II (1471) 



Concerning the influence of antipyretics on the acuity of hearing. 

 By D. I. Macht, J. P. Greenberg and S. Isaacs. 



[From the Johns Hopkins University, Baltimore, Md.] 



In connection with an extensive pharmacological and psycho- 

 logical study of antipyretic drugs, the effect of same was tried 

 on the acuity of hearing. Experiments were performed on normal 

 human subjects, and in a few cases on persons suffering with mild 

 deafness. The tests were made, by means of a watch, in a quiet 

 room, with the subject in a sitting position; and all necessary 

 controls were carried out for the elimination of error. In every 

 experiment the normal limit of hearing was first determined; the 

 drug to be studied was then administered by mouth; and the 



