8o Scientific Proceedings (104). 



Substance. 



Minimal Lethal 

 Dose per 20-30 

 G. White Mice 

 Mgms. 



Quantity Non- 

 lethal Intraven- 

 ously in Dogs, 

 Gms.per Kilo. 



Minimal Effec- 

 tive Anesthetic 

 Concentration 

 on Rabbits' 

 Cornea, 



Minimal Effec- 

 tive Anesthetic 

 Concentration 

 in Human 

 Skin, i. 





50 1 



0.2 1 



I.25 3 



I/30 2 





20 2 



O.I 2 



0.75 2 



I/40 2 



/3 Phenethylol 



40 3 



0.2 3 



I.OO 3 



I/40 3 , 4 





4O 2 



0.2 2 



O.5O 2 



I/40 2 



1 Macht. 



2 Hjort and Kaufmann. 



3 Hjort and Eagan. 



4 (1/40) 13 wheals in 21. 



Sollmann 6 found that procaine in the strength of 1/32 per cent, 

 was the minimal concentration which anesthetized human skin 

 when injected intradermally and tested according to the wheal 

 method of Hoffmann. 7 From the above table, therefore, it is 

 seen that benzoyl carbinol is at least as efficient on the human skin 

 as any known anesthetic. 



Benzoyl carbinol is not as irritant on the tongue as the benzyl 

 alcohol and its above mentioned homologues. In the skin, like- 

 wise, it does not induce as extensive a local reaction of the tissues. 

 It is soluble in water to the extent of about one half per cent, at 

 20 0 C, but when heated to 50 0 C. a one per cent, solution can be 

 made which does not alter within two hours. Benzoyl carbinol is, 

 therefore, soluble within practical limits. 



Summary. — 1. Benzoyl carbinol possesses local anesthetic 

 properties which in general are superior to those of its homologues 

 herein discussed. 



2. Benzoyl carbinol is less irritant to the body tissues than its 

 congeners. 



3. Its solubility in water is sufficient to make it a practicable 

 local anesthetic. 



4. It is the most stable of the series. 



6 Sollmann, T., Ibid., 1918, xi, 69. 



7 Hoffmann, u. Kochmann, Beit. Klin. Chir., 1914, xci, 489. 



