Studies in the Absorption of Fats. 89 



and the animal is asphyxiated under conditions which permit the 

 eye changes described above, there is a similar primary rise due to 

 adrenal secretion, followed by the secondary thyroid effect. 



7. If the thyroid glands have been previously removed, sensory 

 stimulation and asphyxia induce only the increase of rate due to 

 adrenal discharge. 



53 (1513) 



Studies in the absorption of fats. 



By T. F. ZUCKER. (By invitation). 



[From the Department of Pathology, College of Physicians and 

 Surgeons, Columbia University.] 



The general impression of workers in the field of fat metabolism, 

 with regard to the path of absorption, seems to be that while 

 most of the fat enters the circulation by way of the thoracic duct, 

 a smaller portion can be absorbed directly into the blood stream. 

 The most recent discussion of the subject is by Bloor. 1 The 

 results of previous workers are, briefly, as follows: Walther 2 

 recovered in anesthetized animals only a small fraction of the 

 absorbed fat from the lymph of the thoracic duct. Munk and 

 Rosenstein 3 recovered from the discharged lymph 60 per cent, 

 of the fat fed to a patient with lymph fistula. Frank 4 tied off 

 the thoracic duct after feeding fat and still found the fat of the 

 blood to increase during absorption. Hamburger 5 tied off three 

 equal-sized loops of intestine and in the central loop ligated all 

 lymph vessels. Then after injecting an oil and soap emulsion, 

 he noted that this was absorbed from the central loop despite 

 the tying off of the lymph vessels, although it was distinctly less 

 in amount than in the control loops. Munk and Friedenthal, 6 

 in a preliminary communication, describe experiments similar 

 to those of Frank, but use more precautions, such as tying off the 



1 Bloor. Jour. Biol. Chem., 1916, XXIV, 457. 



2 Walther, Archiv. f, Physiologic 1890, p. 328. 



3 Munk and Rosenstein, Virchow's Archiv, 1891, CXXIII, 230. 



4 Frank, Archiv. f. Physiologic 1892, p. 497; 1894, p. 297. 

 6 Hamburger, Archiv. f. Physiologic 1900, p. 554. 



6 Munk and Friedenthal, Zentralb. Physiologic 1901, XV, 297. 



