Local Tissue Reactions. 



93 



cases reached the maximum from 0.13 to 0.15 per cent, at the end 

 of one hour and in two hours time returned to normal. In hypo- 

 functions of the endocrine system, there was noted practically 

 no increase in the blood sugar; on the contrary hyperfunction 

 of the thyroid produced a pronounced hyperglycemia after the 

 glucose ingestion which persisted for 4 to 5 hours. In the hourly 

 specimens of urine from these cases there was an evident glyc- 

 uresis, which for a period of 3 hours totaled 1.4 per cent, of the 

 glucose given. These specimens of urine gave positive reactions 

 for sugar with Benedict's qualitative copper solution. The normal 

 cases excreted during 3 hours from 0.1 to 0.2 percent, of the glucose 

 given and gave negative reactions with the copper reagent. 



The diastatic activity of the blood was found to be decreased 

 in dyspituitarism, acromegaly and Addison's disease, but in 

 hyperthyroidism there was a distinct increase ranging from 20 to 

 34, except in 2 very early cases. 



55 (1515) 



The influence of systemic changes on local tissue reactions. 



By John Auer. 



[From the Laboratories of The Rockefeller Institute for Medical 



Research.] 



In order to explain the occurrence of a massive, brawny edema 

 at the site of operative wounds in sensitized, reinjected dogs, the 

 following working hypothesis was formed: Sensitized animals 

 which have circulating ineffective amounts of the antigen, may 

 react locally with anaphylactic changes if through any mechanism 

 (for example, by inflammation and edema) an effective dose of the 

 antigen accumulates in those tissues. 



This conception was then tested experimentally in the rabbit. 



Rabbits were sensitized by four muscular and intraperitoneal 

 injections of 4 c.c. horse serum at 4 to 5 day intervals. 15 to 21 

 days after the last injection, 10 c.c. of horse serum were given 

 intraperitoneally. 30 to 45 minutes after the reinjection, none of 

 the rabbits having shown any collapse, the hairy surface of the 



