Phenol Elimination in the Dog. 



103 



to the medium in which the tissues were suspended. The following 

 organs were examined: Uterus and Fallopian tube, bladder and 

 ureters, and vas deferens and seminal vesicle. Aqueous saline 

 extracts of the ram's, dog's, bull's, steer's and human prostate 

 glands were used. It was found that all of the above organs are 

 stimulated in vitro by prostatic extracts, provided a sufficient 

 dose is used; but that different organs require different doses of 

 the glandular extract. The uterus and tubes were found to 

 respond to the smallest quantities of prostatic extract; the bladder 

 and ureters came next in the order of their response to such treat- 

 ment; while the vas deferens and seminal vesicles required the 

 largest doses of the extracts to give evidence of any physiological 

 effect. As a result of the experiments, the authors conclude that 

 the prostatic extracts cannot be regarded as having any specific or 

 marked influence on the tonus and contractions of the bladder in 

 vitro. Fuller data will appear in due time in the Journal of 

 Urology. 



62 (1522) 



Phenol elimination in the dog after intravenous injection of 

 neoar sphenamine . 



By Charles Weiss 



[From the Dermatological Research Laboratories, Philadelphia, Pa.] 



Although Ehrlich himself recognized the importance of dis- 

 covering the fate of salvarsan in the animal body, it was Sieburg 1 

 who first approached the solution of this problem. This in- 

 vestigator succeeded in isolating from the urine of a syphilitic 

 patient who had received repeated intravenous injections of 

 salvarsan the following substances: ^-aminophenol, o-acetylamino 

 phenyl hydrogen sulphate, oxycarbanil, an aminohydroxypheny- 

 larsonic acid, C 6 H 8 0 4 N As, and a hydroxy phenylarsonic acid, 

 C 6 H 7 04As, besides inorganic arsenates and arsenites. He con- 

 cludes that salvarsan is broken down in the system in the following 

 way (Chart 1) : 



1 Sieburg, E., Zeitschr. physiol. chem., 1916, 97, 53-108. Abstr. in Chem. Ab- 

 stracts, 19 1 7, 2, 270-1. (Original article not available in U. S. A.) 



