io6 



Scientific Proceedings (105). 



third period of five days there is a return to practically normal 

 excretion. 



3. The injection of a dose of 0.841 gr. of neo-arsphenamine 

 results in the elimination of a total of only 74 mg. "extra" phenols 

 during a period of 15 days; 81 per cent, of this is in the conjugated 

 state. Of the "normal" phenols only from 10 per cent, to 30 

 per cent, is conjugated. Since in the colorimeter I mg. of neo- 

 arsphenamine reacts like 0.466 mg. phenol, we have the striking 

 observation that only 9.2 per cent of the dose of the drug injected 

 is eliminated in the urine in the form of a phenol or phenol deriva- 

 tive. This suggests the following possibilities: (a) Some of the 

 drug is eliminated as phenols in the feces; (b) a portion of it is 

 burned; (c) a portion is retained or "fixed" by the various tissues, 

 notably the liver, for a period much longer than 15 days; (d) most 

 of the drug is oxidized to the stage of inorganic arsenic and elimi- 

 nated as such; (e) a portion is eliminated as nitro-phenols which 

 do not react with the Folin reagent. The latter suggestion seems 

 the most improbable but not impossible. 



table 2. 



Phenol Elimination after Injection of Neo-arsphenamine and Ammonium 



Persulphate. 1 





Normal 



Persul. 



1st Period 



2d Period 

















Control 



Control 



Neo. and 



Neo 



and 



Summary. 











Period. 



Period. 



Persul. 



Persul. 















Daily 



























































Elimination. 

































V 

 V 



i 

 0 



V 

 V 



0 



V 



V 





■ 



V 



£ 



3 



Periods. 



■ 



e 



a 



0 



'c 

 0 



1 



I 

 u 





£ 



H 



£ 



H 



£ 











m 



h 



U 





tS 



1st day. . . 



99 



154 



137 



188 



136 



190 



235 



265 



Normal 

































523 



775 



252 



68 



32 









































5 days with 













2d M ... 



91 



154 



128 



181 



191 



272 



263 



301 



persul. only . 

 1st period 

 after neo 



604 



834 



230 



73 



27 



3d - ... 



106 



152 



106 



135 



137 



188 



320 



365 



and persul.. . 

 2d period 

 after neo 



885 



1. 163 



278 



76 



24 



4th " ... 



"3 



153 



124 



173 



212 



265 



275 



33i 



and persul.. . 

 Total 10 

 days neo 



1,426 



1,630 



204 



88 



12 



5th " ... 



114 



162 



IO9 



157 



209 



248 



333 



368 



and persul.. . 

 "Extra" 



2,311 



2,793 



482 



83 



17 



Total 



















phenols 













5 days . . . 



523 



775 



604.834 



885 



1. 163 



1,426 1,630 



10 days 



1. 103 



1. 123 



., 



98 



2 



All figures refer to miligrams. 



