148 



Scientific Proceedings (107). 



tion of the motor nerves of the abdominal musculature in preg- 

 nancy is not more effective in causing alterations of the pressure 

 curve than in the non-pregnant cat. The function appears to 

 be part and parcel of the musculature itself rather than of the 

 extrinsic nerves, although some slight nervous regulation and 

 coordination does undoubtedly exist. 



79 (1539) 



Coli fever and blood volume in dogs. 



By H. G. Barbour and A. J. Howard. 



[From the Pharmacological Laboratory of the Yale University School 



of Medicine.] 



For the continuation of work on the mechanism of fever reduc- 

 tion by drugs we have been seeking a satisfactory method of 

 producing fever in dogs. In these animals a predictable curve of 

 neurogenic fever is very difficult if not impossible to obtain. 

 A few injections of peptone have given us a maximum rise of less 

 than i° C. with a rapid return to normal within two or three 

 hours (maximum dose employed: 7 c.c. per kilo of 67 per cent, 

 "bactopeptone.") 



Turning to injections of killed cultures of colon bacilli we made 

 nineteen experiments with subcutaneous injections of a vaccine 

 containing 325,000 million bacilli per c.c. and in fourteen of these 

 obtained a temperature the following morning (that is, after 15 

 hours), varying from 0.4 0 to 1.7 0 C. above normal. In the other 

 five, no elevation of temperature was seen. 



The next procedure was to inject in the morning, following the 

 curve throughout the day. For this purpose a more concen- 

 trated vaccine was selected, containing 1,625,000 million bacilli 

 per c.c. In five uncomplicated experiments in which this vaccine 

 was used, maximum temperature increases of 2.4 0 to 1.5 0 C. 

 (with hourly readings) were obtained with doses of 1 c.c. per 

 kilo. With yi c.c. per kilo the maximum increase was 2.4 0 . A 

 smaller dose (0.2 c.c. per kilo) gave, however, an increase of only 



