150 



Scientific Proceedings (107). 



Changes in the blood volume of coli fever dogs were followed by 

 means of hourly determinations of hemoglobin and blood solids. 

 In uncomplicated experiments the blood solids showed constantly 

 an increase running parallel with the increase of body temperature. 

 This increase varied at the maximum point from 3.3 to 7.6 per 

 cent, in five different animals. It is illustrated in the accom- 

 panying figure (A) as well as in Figures 2 and 3 of the following 

 paper on dextrose plethora. Similar hemoglobin changes were 

 quite definite in some cases. 



The increase in the percentage of the blood solids is interpreted 

 as a diminution in the volume owing to loss of water. We are 

 not yet prepared to discuss the fate of this water, but have noted no 

 significant increases in the amount of urine. The loss of water 

 from the circulation is probably the chief factor in the decreased 

 heat dissipation which accompanies the initial rise of temperature 

 in infectious fevers. 



80 (1540) 



Dextrose plethora and its antipyretic effect in coli fever. 1 



By H. G. Barbour and A. J. Howard. 



[From the Pharmacological Laboratory of the Yale University School 



of Medicine.] 



The antipyretic action of dextrose was pointed out by one of 

 us in the Proceedings of this Society about one year ago in 

 connection with observations upon rabbits with peptone fever, 

 and febrile human individuals to whom the sugar had been admin- 

 istered by mouth. 2 In view of the experiments reported some 



1 The assistance of an appropriation from the Bache Fund of the National 

 Academy of Sciences in support of the researches reported in this and in the preceding 

 paper is gratefully acknowledged. 



The authors desire to thank Dr. George H. Smith, of the department of bacteriol- 

 ogy, for valuable assistance in the preparation of the greater part of the coli vaccines 

 used in this work. 



'"The Antipyretic Action of Dextrose," Proc. Soc. Exp. Biol, and Med., 

 1919. XVI, 136. 



In connection with the demonstration that antipyretic drugs increase the blood 

 sugar this has been interpreted as a potent factor in their action. See Barbour and 

 Herrmann, "On the Mechanism of Fever Reduction by Drugs," Proc. Nat'l. Acad, 

 of Sci., 1920, VI, 136. 



