Scientific Proceedings (107). 



It was found that morphin, in both large and small doses, 

 impaired the memory and the behavior of the rats. In the case 

 of only one of the animals was there an excitation or stimulation 

 noted after small doses of the drug. After large doses of morphin, 

 the impairment was long-lasting, continuing for several days. 

 In most cases, however, the animals eventually completely recov- 

 ered from the effects of the narcotic. 



In regard to the comparative effects of morphin alone and 

 morphin given in combination in the form of pantopon or narco- 

 phin, the following interesting observations were made: Out of 

 26 experiments with pantopon and morphin, in 22 the effects of 

 morphin were found to be more depressant than those of pantopon. 



Out of 9 experiments with morphin and narcophin on the same 

 animals, 7 experiments showed that morphin was more depressant 

 than narcophin. In all the experiments with the opium alkaloids, 

 the effects were noted on both the time in which the rats went 

 through the maze and the total distance traversed or the number of 

 errors made. 



Codein, in 9 experiments out of 11, produced impairment, 

 as indicated by both the time and the distance. Narcotin, in 

 5 experiments out of 7, produced also a depression. Narcein, 

 out of a total number of 10 experiments, produced a slight depres- 

 sion in 4, and no effect in 6. Thebain indicated a slight retarda- 

 tion in 10 experiments out of 11. In the case of papaverin, it was 

 found that very little effect was produced by small doses of the 

 drug, but that after large doses (10 or 15 mgs.), a depression was 

 noted. The complete data of this research will appear in due 

 time in the Journal of Pharmacology and Experimental Therapeutics, 



88 (1548) 



On the generalization of treponema pallidum in the rabbit fol- 

 lowing local inoculation. 



By Louise Pearce and Wade H. Brown. 



[From the Laboratories of the Rockefeller Institute for Medical 

 Research, New York.] 



That a widespread dissemination of Treponema pallidum 

 may be produced in the rabbit by local inoculation has been shown 



