Blood Changes in Ether Anesthesia. 169 



ment of a primary lesion plus an effect which appeared to be 

 attributable to the early removal of even the small bit of syphilitic 

 tissue used in the process of inoculation by the implantation of a 

 small piece of infected testicle beneath the skin of the right 

 scrotum. 48 hours later, the entire scrotum and testicle were 

 amputated under ether anesthesia. By the end of the 7th week, 

 8 of the 10 rabbits had developed marked generalized syphilis 

 while the other 2 showed a definite lymphadenitis. One of these 

 developed slight generalized lesions at the end of 2 months and 

 the other 2^ months after inoculation. As a whole, however, 

 the generalized infection was the most pronounced which we have 

 seen in any single group of animals. 



Conclusions. — The conclusions to be drawn from these experi- 

 ments are : That the marked character of the reaction which takes 

 place in the rabbit following local inoculation of old strains of 

 Treponema pallidum is in a large measure responsible for the 

 absence of generalized lesions; that an inhibitory influence is 

 exerted upon the development of other lesions which is proportion- 

 ate to the reaction taking place at the site of inoculation and that 

 the reduction, suppression or prevention of this reaction will 

 remove this influence to a sufficient extent to permit the develop- 

 ment of a generalized disease analogous to that which occurs in 

 man. 



90 (1550) 



Blood changes in ether anesthesia. 



By Donald D. Van Slyke, J. Harold Austin and Glenn E. 



Cullen. 



[From the Hospital of the Rockefeller Institute for Medical Research , 



New York.] 



During light ether anesthesia the bicarbonate content of the 

 arterial blood falls, the carbon dioxide tension (determined 

 directly by the tonometric method on the blood) rises, as does the 

 hydrogen ion concentration. These phenomena indicate a state 

 of uncompensated acidosis. The oxygen saturation increases, 

 indicating that ventilation is accelerated in response to the stimulus 



