174 



Scientific Proceedings (108). 



curred (17-28 per cent.), but the hourly heat production is practi- 

 cally the same after the meal as it was in the first observation. 

 The nitrogen excretion was much increased after the meat. 

 The quotients are normal throughout and higher than after fasting. 



The explanation of the diabetic respiratory quotient has been 

 made by Lusk 1 who estimates the amount of oxygen and carbon 

 dioxide exchanged in respiration for each gram of urinary nitrogen 

 in severe diabetes (D : N = 3.65). In the case of a dog with 

 phlorhizin glycosuria, and the cases of two diabetic men, diabetic 

 quotients were obtained, but non-protein quotients were found to 

 closely approximate that for fat. In the present case the non- 

 protein quotients are below that for fat, due to a failure of all of 

 the nitrogen metabolized to appear in the urine. 



It seems probable that the diabetic quotients in this case were 

 obtained by the same mechanism as in diabetes, except that the 

 glucose instead of being excreted in the urine, was stored as 

 glycogen. 



TABLE I. 



Effect of 350 Gm. Meat on a Fasting Man, Age 23, Wt. 70.4 Kg., Ht. 180 Cm. 



Hours. 



Before- 



-Basal. 



Eating. 



After. 





2. 



3- 



4- 



5- 



6. 



CO2 gm 



22.92 



22.46 





23.02 



23-73 



24-34 





22.73 



22.60 



Protein 



24-38 



25-36 



23.91 



R.Q 



•733 



•723 



70 gm. 



.687 



.681 



.740 





•639 



.639 



Fat 



•637 



.637 



•637 



Cals. per hour 



73-85 



73-36 



28 gm. 



78.77 



81.98 



77-89 



Observation 391 made at the end of an 8 day fast. 



Table II. 



Behavior of the Same Individual One Week Later, having been on a Normal 

 Diet in the Interval. 



Hours. 



Basal. 



Eating. 



After. 



■• 



1 



3' 



4- 



5- 



6. 





20.67 



29.88 





23.89 



26.60 



25-97 





19.09 



19-53 





22.82 



24.96 



24.91 



R.Q 



.788 



.778 





.762 



•775 



-758 





•599 



•599 





1.020 



1.020 



1.020 



Cals. per hour 



62.81 



64.11 





74-08 



81.38 



80.98 



The same meal was given after a basal observation. 



'Lusk, Graham, "On the Diabetic Respiratory Quotient." Arch. Int. Med., 

 1915, is, part H, p. 939- 



