Phenylcinchoninic Acid. 



187 



lesions of the same nature as described above. However, the 

 lesions did not appear until about 10 days after exposure. The 

 young were born 2 days after treatment and appeared normal. 

 After about a week they began to fail considerably, hemorrhagic 

 areas appeared along the mid-dorsal line, especially in the head 

 region and death followed. The hemorrhages in these animals 

 were mainly along the meningeal sinuses (figures shown), in some 

 cases frontal and occipital hemorrhages were just beginning, in 

 others they extended considerably over the cerebral hemispheres. 

 Additional lesions on the dorsal side of the thorax were found. 



The interval of 10 days after treatment strictly corresponds 

 to the time at which a primary skin erythema develops in radium 

 treated patients. Again it seems as if the endothelial walls had 

 been injured at the time of exposure and gradually gave way to 

 the blood pressure. 



In the course of the experiments, we also found numerous 

 hemorrhagic areas in the uteri and especially in the ovaries 

 (figures shown). Congestion of the uterine vessels always was 

 pronounced. 



While in experiments on adult animals reported by Bagg 

 before, the injection of radium emanation led to considerable 

 injuries in the internal organs, in our experiments the weaker 

 doses did not produce any macroscopically visible effects on the 

 maternal tissues. However, the embryonic differentiating tissues 

 were easily affected. This fact might be of some biological signi- 

 ficance, when one remembers that radium rays have a decided 

 effect on fast growing tumor and cancer tissues. 



99 (1559) 



The influence of phenylcinchoninic acid and its methyl derivative 

 on the uric acid and urea content of the blood. 



By V. C. Myers, J. A. Killian and G. E. Simpson. 



[From the Laboratory of Pathological Chemistry, New York Post- 

 Graduate Medical School and Hospital.] 



It has been recognized now for some time that the adminis- 

 tration of salicylates and phenylcinchoninic acid (cinchophen) 



