1 88 Scientific Proceedings (108). 



resulted in an increased excretion of uric acid in the urine. Quite 

 recently it has been shown by Folin and Lyman, 1 and Fine and 

 Chace, 2 in particular, that this action was accompanied by a marked 

 drop in the uric acid content of the blood, and later the same was 

 shown to be true of salicylates by Fine and Chace, 3 and Denis. 4 

 It has been assumed that these drugs induce an increased output 

 of uric acid by endowing the renal cells with an increased power 

 for eliminating uric acid. Fine and Chace 5 have pointed out that, 

 in the last stages of interstitial nephritis cinchophen has little 

 influence on the excretion of the uric acid, indicating that the 

 renal cells can no longer be stimulated to increased activity. 



Influence of Phenylcinchoninic Acid and its Methyl Derivative on the 

 Uric and Urea Content of the Blood. 



Case. 



Date 1920. 



Uric Acid 



Urea N 



Creatinine 



Mg. to 100 C.c 



Mg. to 100 C.c. 



Mg. to 100 C.c. 



I. M.G 



3/26 



6.0 



29 



i-S 





3/28 



5-2 



29 



2.4 





3/31 



trace 



16 



2.0 





4/ 5 



3-0 



24 



2.2 





4/12 



3-5 



18 



30 





4/i3 



3-9 



IS 



2.4 



2. M.D 



3/i6 



2.8 



26 



2.6 





3/i8 



2.8 



22 



2.6 





3/22 



trace 



13 



2.7 





3/25 



2.6 



20 



2.4 





3/29 



2.6 



19 



2.2 





4/ 9 



2.8 



16 



2.4 





4/12 



0.7 



13 



2.6 





4/15 



2.0 



17 



2.4 



Case If male, aged 58; clinical diagnosis, chronic interstitial nephritis, arterios- 

 clerosis; 50 grains tolysin daily 3/28 to 4/3. 



Case 2, female, aged 53; clinical diagnosis, neurasthenia, visceroptosis; vegetable 

 diet; 50 grains tolysin daily 3/19-22; 50 grains cinchophen daily 4/9-12. 



We have been endeavoring to obtain further light on the 

 mechanism of the action of these drugs by experiments upon both 

 man and animals. Setting aside cases of advanced interstitial 

 nephritis where the action of cinchophen is comparatively slight, 

 we have been struck by the fact that this drug and its methyl 



1 Folin and Lyman, Jour. Pharmacol, and Exper. Therap., 1912-13, IV, 539. 



2 Fine and Chace, Jour. Pharmacol, and Exper. Therap., 1914, VI, 219. 

 •Fine and Chace, Jour. Biol. Chem., 1915, XXI, 371. 



4 Denis, Jour. Pharmacol, and Exper. Therap., 1915, VII, 255, 601. 

 'Fine and Chace, Arch. Int. Med., 1915, XVI, 401. 



