52 Scientific Proceedings (125) 



hold as immediately responsible for metamorphosis) has been 

 greatly postponed. A pronounced darkening of the axolotl re- 

 sulted from these injections of anterior lobe substance, the 

 specimen becoming after repeated injections a jet black 



22 (1982) 



Reactions of the capillary endothelium in peptone shock. 

 By W. H. MANWARING, WALTER H. BOYD and WILLIAM O. FRENCH 



[From the Laboratory of Experimental Pathology, Stanford Uni- 

 versity, Sa?i Francisco, California) 



The fundamental reacting tissues in peptone shock are not the 

 same as the fundamental reacting tissues in thje acute anaphylactic 

 shock of dogs. Canine anaphylactic shock is dependent upon 

 liver function 1 . Canine peptone shock is not dependent upon 

 hepatic function, since reactions apparently identical with those 

 of the intact animal are produced by intravenous injections of 

 peptone into dehepatized (Dale and Laidlaw's Eck-fistula 2 ) dogs 

 and into eviscerated dogs. 



Marked peptone reactions are demonstrable in isolated canine 

 tissues. These reactions are produced by perfusing the tissues 

 with Ringer's solution containing 1 per cent. Witte's peptone. 

 More marked reactions are obtained by perfusing with de- 

 fibrinated-blood-peptone mixtures, or with uncoagulated-blood- 

 peptone mixtures. The principal reactions of the isolated canine 

 tissues thus far studied are : 



(a) Liver. Marked increase in perfusion resistance, reach- 

 ing a maximum by the end of ninety seconds. The resistance 

 then gradually decreases, and is almost completely restored to 

 normal by the end of eight minutes. 



(b) Lungs. Reactions similar to those of the liver, but 

 more pronounced, with little or no tendency to recovery by the 

 end of eight minutes. 



(c) Intestines. Distinct decrease in perfusion resistance, 

 reaching a maximum by the end of ninety seconds. Slight 

 tendency to recovery by the end of eight minutes. 



i W. H. Manwaring, Zcitschr. f. Immunitiitsf., 1911, viii, 1. 

 2H. H. Dale and P. P. Ivaidlaw, Jour. Physiol, 1018-19, lii, 351. 



