t 



Therapeutic Efficiency of Arsphenamine 59 



M. E. I). Arsphen. 



Ratio — .48. 



M. E. D. Neo-Arsph. 



Arsphenamine and Gelatin- Arsphenamine 



M. L. D. (100) 



Therap. Index Arsphen. — 10. 



* M. E. D. (10) 



M. L. D. (140) 



Therap. Index Gel. Arsp. = 14. 



v M. E. D. (10) 



Therap. Index Gel. Arsp. 



Ratio = — — 1.4. 



Therap. Index Arsphen. 



M. E. D. Arsph. 



Eatio = 1. 



M. E. D. Gel. Arsph. 



MINIMUM STERILIZING DOSE 



Schamberg, Kolmer and Raiziss 



M. T. D. (105) 



Therap. Index Arsphen. — 4.5. 



M. S. D. (23) 



M. T. D. (254) 



Therap. Index Neo-Arsph. = 6.3. 



M. S. D. (40) 



Therap. Index Neo-Arsphen. 



Ratio = 1.39. 



Therap. Index Arsphen. 



M. S. D. Arsphen. 



Ratio — .57. 



M. S. D. Neo-Arsph. 



M. T. D. (90) 



Therap. Index Arsphen. ■ — 4.5. 



M. S. D. (20) 



M. T. D. (130) 



Therap. Index Gel. Arsph. — 6.5. 



M. S. D. (20) 



Therap. Index Gel. Arsph. 



Ratio - = 1.4. 



Therap. Index Arsph. 



M. S. D. Arsphen. 



Ratio — 1. 



M. S. D. Gel. Arsp. 



l The greater magnitude of these ratios as compared to our figures and 

 those of Schamberg et. al. is the result of the high lethal dose. This ii doubt- 

 less due to the shorter period of observation, 48 hours instead of two weeks, 

 which Voegtlin used. 



M. L. D. = minimum lethal dose. M. S. D. — minimum sterilizing dose. 



M. E. D. = minimum effective dose. M. T. D. — maximum tolerated dose. 



