Pancreatic Factor in Intestinal Obstruction 85 



41 (2001) 



The pancreatic factor in intestinal obstruction. 

 By H. B. EISBERG. 



[From the Department of Experimental Surgery, University and 

 Bellevue Hospital Medical College, New York City.] 



In a previous communication 1 some experiments on the pan- 

 creas in relation to intestinal obstruction were reported. This 

 presentation includes a duplication of the work with additional 

 data. Twenty-three dogs were used. The experiments were 

 divided into five groups. 



Group I : Duodenal occlusion, pancreatic occlusion, 2 number 

 of dogs, 5. 



Average duration of life, 76.6 hours. Observations : A mild 

 toxaemia developed which did not stimulate the toxaemia of 

 duodenal obstruction. Autopsy revealed a slight congestion of 

 the duodenal and colon mucosa. Microscopic examination of 

 the pancreas 3 showed a capillary congestion, nuclei indistinct 

 and the ducts filled with secretion. 



Note: An accidental traumatic pancreatitis and a partial de- 

 vitalization of the oral duodenum was responsible for a severe 

 toxaemia in two of these cases. These variables were not in- 

 cluded in estimating the mean duration of life. 



Group II : Duodenal occlusion, partial pancreatic resection 

 (duct bearing portion), number of dogs, 3. 



Average duration of life, 43.3 hours. Observations : The 

 symptoms of duodenal obstruction were greatly accentuated 

 owing to the associated pancreatitis. Autopsy revealed a con- 

 gestion of the peritoneum, also a slight congestion of the duo- 

 denal and colon mucosa. Fat necrosis was present in each case. 

 Microscopic examination of the pancreas showed a haemor- 

 rhagic infiltration with cells in different degrees of auto-diges- 

 tion. 



Group III : Duodenal occlusion, pancreatic excision, number 

 of dogs, 5. 



1 Eisberg, H. B., Annals of Surgery, 1921, Lxxdv, 584. 



2 Sweet, J. E., Peet, Max M., Hendrix, B. M., Annals of Surgery, 1916, 

 Lxiii, 720. 



3 Fraser, A., Personal communication. 



