128 



Scientific Proceedings (127) 



clays. The urines were evaporated and extracted with the same 

 alcohol ether mixture. From this extract or from the water 

 solution of the residue of this extract, we recovered 2.3 grams 

 of the ingested hippuric acid without difficulty. 



It would seem then that starving hens do furnish a very small 

 amount of ornithine when this is necessary for the detoxication 

 of benzoic acid. Contrary to the claims of Suga however, we 

 were unable to find even a trace of hippuric acid in the urine of 

 well fed birds after the feeding of benzoic acid but instead only 

 benzyl ornithine or free benzoic acid and like Yoshikawa we 

 believe that birds are unable to furnish glycocoll for detoxica- 

 tion purposes and even unable to make use of it, if it is fur- 

 nished them from exogenous sources. 



63 (2023) 



The experimental production of gall-stones in dogs, in the 

 absence of infection, stasis, and gall bladder 

 influence upon the bile. 



By PEYTON ROUS, P. D. McMASTER, and G. O. BROUN. 



[From the Rockefeller Institute for Medical Research, New York 



City.} 



Numerous circumstances and influences which favor the devel- 

 opment of gall-stones are now recognized, but uncertainty exists 

 as to which of them are contributory in character and which 

 critical, and as to whether indeed the decisive causes for chole- 

 lithiasis are to be found amongst them. In this connection, 

 observations under controlled conditions in animals possess 

 interest. 



By a method elsewhere reported, 1 it is possible to join a rubber 

 tube to the common duct of a dog and collect the bile under sterile 

 conditions for months. The gall bladder should be removed at 

 the time of intubation. Our animals thus treated remained in 



1 Rous, Peyton, and MeMaater, P. D., Jour. Exp. Med., 1923, xxxvii, 11. 



