130 



Scientific Proceedings (127) 



bonate in the stones of the dog has similarities to that between 

 calcium bilirubinate and cholesterol in human calculi. There is 

 the same tendency in both instances for a nucleus of the pigment 

 material to be overlaid with another substance. 



The observations here reported show that infection is not the 

 essential factor in cholelithiasis. That it frequently plays the 

 determining role is equally certain." This it would seem to do 

 by damaging the duct wall with result in desquamation, — which 

 the sterile canula did in our experiments, — and by lessening the 

 ability of the bile channels to rid themselves of the cell debris. 

 The debris induces, or furthers, the direct deposition of solids, 

 and may catch and retain potential nuclei for stone formation, 

 in the shape of pigment particles from higher up in the biliary 

 system, which would under ordinary circumstances be voided 

 with the bile. 



64 (2024) 



The paradoxical shortening of blood coagulation after intra- 

 venous administration of sodium citrate. 



By NATHAN ROSENTHAL and GEORGE BAEHR. 



[From the Department of Pathology and the First Medical Service, 

 Mount Sinai Hospital. New York City.] 



Sodium citrate, when administered intravenously in large 

 doses (0.5 grams for dog or cat, 3.0 to 6.0 grams for man), 

 produces a pronounced and progressive shortening in coagulation 

 time of the blood which usually reaches its maximum within 

 one hour and may persist for many hours. As a rule, the coagu- 

 lation time slowly returns to normal within twenty-four hours. 



This action of sodium citrate upon the coagulation of the 

 blood in vivo is exactly opposite to what occurs in vitro. We 



2 Gilbert, A., et Founder, L., Sc. et mem. de la Soc. dc Biol., 1897, it, 10 

 Bear., 930; Mignot, B., Arch. gen. de Med., 1898, i, 129. 



