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Scientific Proceedings (127) 



retention per day. However, when the values are computed it 

 is found that of this alkali retained, 2 c.c. is required for the 

 protein increase, 4 c.c. for the alkali reserve and about 57 c.c, 

 by far the greatest part, for the building of bone. 



The effect of acids and alkalis added to the diet has also been 

 studied. When 250 c.c. of 0.1N HC1 was given baby A he 

 retained 67 c.c. of alkali in excess of acid. When 4 grams of 

 sodium bicarbonate, equivalent of 473 c.c of 0.1N alkali was 

 given to baby B he retained 114 cc. of base in excess of acid. 

 This is a quantative measure of the effect of acidosis and alka- 

 losis in relation to alkali retention and growth. 



It is hoped that studies of this type now being pursued will 

 yield further information on the problems of growth, nutrition 

 and normal and pathological mineral metabolism. 



69 (2029) 



On the effect of certain drugs, notably quinine, on the acuity of 



hearing. 



By A. G. POHLMAN and F. W. KRANZ. 



[From the Department of Anatomy, St. Louis University, St. 

 Louis, Mo., and Wallace Clement Sabin Laboratory 

 of Acoustics, Riverbank, Geneva, III.] 



The purpose of this investigation was to determine the de- 

 gree of deafness following the administration of quinine and 

 also to ascertain, if possible, whether or not the tinnitus which 

 accompanies this intoxication has any appreciable effect on the 

 acuity of hearing at any and all pitches. While these experi- 

 ments were under way the writers found that Macht, Greenberg 

 and Isaacs had published a similar investigation in reference to 

 antipyretics. It was thought desirable, for reasons which will 

 appear later, to check on the results obtained by these writers. 

 The quantitative tests submitted in this paper were all made by 

 Kranz 1 with a thermophone provided with a new frequency vari- 



i Kranz, F. W., Phy. Review, 1921, xvii, 384 



