148 



Scientific Proceedings (127) 



the effects of quinine. It was thought essential that the drug be 

 studied in reference to the areas of decreased efficiency to find 

 out if they were depressed as much as the more acute regions. 

 Check reading, however, was also made on the left ear with 

 very similar results. 

 Test A__ 



Twenty five grains of quinine sulphate was taken in five grain 

 gelatin capsules at hourly intervals. The test began soon after 

 the administration of the last dose. The subjective symptoms at 

 this time were : sensation of fullness in the ears and a slight 

 high-pitched tinnitus. Attempts to locate the period of the 

 tinnitus were unsuccessful. It was our intention to follow the 

 tone scale throughout the range for both ears but this was 

 abandoned because the amount of actual decrease in efficiency 

 did not lie beyond a reasonable error in attention. 



j I -| 1 1 1 1 ■ 1 r 



JCS l«* 1K0 J WO 1JW iw« Ml 



CHART II 



The quantities are plotted in Chart II under Test A. While 

 the decreased acuity area at 2460 was located, the peak at 2800 

 was not identified. Accordingly, it was determined to exhibit a 

 larger dose of the drug. 

 Test B. 



Forty grains of quinine sulphate were taken in 15 grain doses 

 one half hour apart from 9 A.M. to 12 :30 P.M. The test began 

 at 3 P.M. Subjective symptons at this time were: a more pro- 

 nounced tinnitus of the same general character, like the locusts 

 singing in the trees; a more marked sensation of fullness in the 

 ears, and some slight amount of impairment of hearing, par- 

 ticularly for high pitched sounds. This test covered the entire 

 range from 256 to 3250 p.p.s. The results have been entered 



