Effect of Certain Drugs ox Acuity of Hearing 149 



on the chart as Test B. While the line for the range Bl goes 

 over fairly well into that of B2, a sharp drop (factor of about 5) 

 was noted in passing to the range B4, where the departure seemed 

 even more pronounced. Two subsequent tests were made over 

 the scale B3 yielded the variations as shown in the lines X and Y, 

 ( factor of about 10). Accordingly a final test was made from 

 2100-2300 (B5) when this same sort of decrease in acuity was 

 again evidenced. 



As in the twenty five grain experiment the subject missed the 

 peak at 2800 and also failed to identify the decreased acuity 

 area at 2460. It was difficult to interprete these variations and 

 three possibilities suggested themselves. First, the variations 

 might be due to fluctuations in the amount of absorption and 

 excretion of the drug; second, they might be due to errors in 

 attention due to the toxicity of the drug itself in its effect on the 

 nervous system; and third, the pronounced tinnitus might of 

 itself decrease the acuity of hearing. 

 Tat C. 



Some four days after Test B. the subject took seventy-five 

 grains of quinine sulphate with the intention of pushing the 

 drug to the limit and also eliminate variations in the amount of 

 absorption by spreading the administration of the drug over a 

 longer period of time. Thirty-five grains were taken from 6 :30 

 to 9:30 P.M. in seven five grain doses. Forty grains were taken 

 in the morning in ten grain doses hourly from 6 :30 to 9 :30. 

 The subject did not find his sleep was materially affected and ate 

 a regular breakfast with enjoyment. The test was begun at 

 10:30 A.M. but had to be abandoned for reasons which will be 

 described more completely elsewhere. The subject became un- 

 conscious and was not able to sit up for the test until 4:30 P.M. 

 It was decided to limit the range from 256 - 1800 p.p.s and 

 these readings have been entered on the chart under the letter C. 

 The readings of CI. C2 and C3 line up fairly well. 



It appeared from comparing the lower range of Test B with 

 that of Test C that the larger dose influenced the lower part 

 of the range more than it did the upper part, although this is 

 by no means to be accepted as conclusive evidence. 

 Test D. 



This was made on the following morning after a fairly good 

 night's sleep and has been entered under the line marked with 



