182 



Scientific Proceedings (127) 



Abstracts of Communications 

 Pacific Coast Branch 

 Thirty-fifth meeting. 

 San Francisco, California, December 6, 1922 

 86 (2046) 



The dominant reacting tissues in anaphylactic, peptone and 

 histamine shock. 



By W. H. MANWARING, R. C. CHILCOTE, W S. CLARK and R. E. 



MONACO. 



[From the Laboratory of Experimental Pathology, Stanford Uni- 

 versity, California.] 



Canine anaphylactic shock, peptone shock and histamine shock 

 are currently assumed to be physiologically identical reactions. 

 In each shock there is a sudden, pronounced fall in arterial 

 blood pressure, the carotid pressure being- reduced to about 25 

 mm. Hg. by the end of two minutes. Recovery usually begins 

 about the tenth minute, the arterial pressure being restored to 

 normal in from 30 minutes to 90 minutes, depending upon the 

 severity of the reaction. In each shock, fatal results may be 

 produced by the injection of large doses or by the use of highly 

 sensitized animals. In each shock there is a pronounced 

 splanchnic engorgement and cyanosis, the production of hemor- 

 rhagic lesions in the intestinal mucosa, and a reduction in blood 

 coagulability. In order to test the assumed physiological identi- 

 ty of the three shocks, we have endeavored to determine the topo- 

 graphical distribution of the dominant reacting tissues in each 

 shock. 



1. Canine anaphylactic shock. Anaphylactic shock (fall in 

 arterial blood pressure) does not take place in dehepatized (Eck- 

 fistula) dogs. This is not only true for the mildly sensitized 

 dogs previously reported, 1 but is equally true for highly sensi- 

 tized dogs giving the fatal type of the reaction. Practically no 

 change in arterial blood pressure is produced in these highly 

 sensitized animals, even on the intravenous injection of as large 

 a dose as 30 c.c. of specific foreign (horse) serum. The liver 



i Manwaring, W. EL, Der physiologische Mechanismua des anaphylak 

 tischen Shocks, Zcitsclir. f. Immunitatsf., 1910, viii, 1. 



