Urine Acidity after Adrenalin Chloride 187 



90 (2050) 



Urine acidity after the injection of adrenalin chloride. 

 By ROGER S. HUBBARD. 



[From the Clifton Springs Sanitarium, Clifton Springs, N. Y.] 



The following experiment was planned to study the effect 

 of adrenalin chloride upon the acidity of the urine, and to de- 

 termine, if possible, whether the "acidosis" which has been de- 

 scribed as one of the results of such injections was due to the 

 respiratory changes which follow the administration of the drug. 

 A normal man (the author) who weighed 165 pounds took a 

 standard simple breakfast on each of four successive days. On 

 each day hourly samples of urine were collected throughout the 

 morning. The collection and determination of the degree of 

 acidity was carried out by the method of Marshall 1 ; other de- 

 terminations were done as described in previous papers 2 . On 

 the second day of the experiment 1 c.c. of a 1 to 1000 solution 

 of adrenalin chloride (Parke-Davis) was injected subcutane- 

 ously into the arm. Samples of blood were collected from the 

 median basilic vein one half hour before and one half, one, and 

 two hours after the injection was given. 



TABLE I 



TIME 



NOTES 



URINE 



BLOOD 



BREATH 

















co 2 











Vol. 



Sp. Gr. 



Reac. 



NH 4 N 



T. N. 



vol. 



Sugar 



co 2 



A.M. 





c.c 





Ph 





mg. 



per cent. 



per cent. 



mm. 



7:00 



began 



















8:00 





35 



1.030 



5.6 



8.7 



666 









8:40 



breakfast 



















9:00 





25 





5.8 



5.0 



447 









10:00 





36 



1.032 



7.3 



10.0 



575 



63.3 



0.111 



36 



10:35 



adrenalin 



















11:00 





56 



1.031 



7.4 



9.8 



659 



51.9 



0.172 



29 



11:35 















51.9 



0.270 





12:00 





37 



1.022 



6.2 



11.4 



449 







32 



12:35 















51.9 



0.111 





1:00 





34 : 



1.027 



5.6 



10.8 



554 | 









U. Biol. Chem,, 1922, li, 3. 



2 Hubbard and Wright, J. Biol. Chem., 1921, xlix, 385; Hubbard and 

 Nicholson, ibid., 1922, liii, 209. 



