Parathyroids 



207 



TABLE L 



Dog EE. Calcium and Phosphorus in Serum Following Injection of 1.6 gm. 

 Calcium Chloride Intravenously. Weight 14.5 kg. 



Time. 



Ca 





1 P 



(inorg.). 



in 100 



c.c. 



of 



serum. 





mg. 







mg. 



June 20 











before 



5.2 







7.9 



11:30 a.m. 



15.8 







7.9 



2:00 p.m. 



10.0 







7.8 



3:30 p.m. 



7.2 







7.9 



8:00 p.m. 



6.6 







8.3 



12:00 a.m. 



5.8 







5.4 



June 21 











11:15 a.m. 



5.3 







6.7 



Remarks. 



11:15 a.m., injection of 16 c.c. 

 10 per cent. sol. of CaCl 2 « 



Table I shows that 15 minutes after the injection the calcium 

 was 15.8 mg. and decreased rapidly; 24 hours after, the calcium 

 had the same value as before injection ; that is, there had disap- 

 peared from the blood an amount of calcium exactly correspond- 

 ing to the amount injected. Assuming an even distribution, the 

 injected calcium would increase the serum calcium to 10.9 mg. ; 

 it will be seen that this level is not reached until about 2 l / 2 hours 

 later; which means that calcium chloride diffuses slowly from 

 the blood. There was also a rise in the phosphates. 



TABLE II. 



Dog II. Calcium Excretion in Urine and Feces, June 20-21, 1922. 



Urine 



Feces 





calcium. 



calcium. 



Total. 



9- 



g- 



9- 



0.042 



0.505 



0.546 



Injected 





0.578 



x\s Table II shows there was excreted an amount of calcium 

 corresponding to the amount injected, but more than 9/10 was 

 excreted in the feces and less than 1/10 in the urine (the colon 

 was rinsed out at the beginning and close of the period). This 

 is remarkable, as the calcium in the blood for some time must 

 have been decidedly above the threshold and still only small 

 amounts passed through the kidneys. This rapid disappearance 

 of calcium may explain why calcium treatment reported by pre- 

 vious workers failed to keep the animals alive. 



