252 



Scientific Proceedings (129) 



fore not represented on the curves noted above. Three ring 

 doves at 34, 35 and 36 days after injection with 1 unit (6 X 

 lethal) gave normal average values of 143, 145 and 155 for 

 these three days; one dove given 4.5 units showed a normal 

 value (155) at 48 hours, but less (110) at 74 hours. One 

 common pigeon (18 X lethal) gave values of 165 after 48 

 hours and of only 70 after 74 hours; this bird showed only 

 15 mgms. sugar after two hours and survived the treatment. 

 Another common pigeon given 3.4 units (10 X lethal) gave 

 a normal value (185) at 32 hours and less than one-half nor- 

 mal (70) at 58 hours. Some of these heavily dosed birds whose 

 sugars were low at advanced periods had probably taken no food 

 during a considerable preceding interval.. 



The fact that many of the ring doves and common pigeons 

 given heavy dosage of insulin were not permitted to take food 

 during about 20 hours preceding dosage, and that sugar samples 

 representing values recorded in the curves were taken as much 

 as 22 hours after injection, raises a question as to the bearing 

 of this circumstance upon the sugar values obtained. Concern- 

 ing this point it is noted that earlier studies 5 have indicated that 

 inanition during 48 hours is practically without effect on the 

 normal blood sugar of the pigeon. Only 7 of the 30 birds 

 included in the curves presented (10-30 x lethal) were in any 

 way restricted in their feeding either before or after injection of 

 the extracts. 



119 (2079) 



Experimental production of streptococcus endocarditis with 

 glomerular nephritis. 



By RALPH A. KINSELLA and C. C. SHERBURNE. 



[From the Medical Clinic, Barnes Hospital, Washington University 

 School of Medicine, St. Louis, Mo.] 



In human patients subacute streptococcus endocarditis is a 

 fatal disease. No authentic report of a recovery has even been 

 published. The mechanism of production of this disease in 



6 Honeywell, Amer. Jour, of Physiol., 1921, lviii, 152. 



