Haemoglobin Injection in Anemia 267 



126 (2086) 



Intravenous injection of hemoglobin in the treatment of anemia. 



By ALICE R. BERNHEIM (by invitation). 



[From the First Medical (Cornell) Division, New York Hospital, 



New York City.] 



Brugsch and Yoshimoto 1 , and Whipple and Hooper 2 have 

 shown that hemoglobin, when introduced intravenously into bile 

 fistula dogs, is converted a short time after injection into bile pig- 

 ment. Whipple and Hooper have also shown that bile pigment 

 circulation does not exist, but that bile pigments are excretions. 



On the other hand, McMaster and Haessler, 3 of the Rocke- 

 feller Institute, using rabbits, have demonstrated that hemo- 

 globin intravenously injected cures anemia. 



With these observations in mind, hemoglobin injections were 

 given to five patients in the New York Hospital (First Medical 

 Division). Altogether eleven injections have been given. The 

 hemoglobin was prepared from fresh human blood. There were 

 two cases of pernicious anemia ; two of secondary anemia, and 

 one of myelogenous leucemia. The results are encouraging, and 

 the work is being continued. 



1 Brugsch and Yoshimoto, Zeitsch. f. Exper. Path. u. Therap., 1910-11, 

 viii, 639. 



2 Whipple and Hooper, Am. Jour. Physiol., 1917, xliii, No. 2. 



3 McMaster and Haessler, Jour. Exp. Med., 1921, xxxiv, 579. 



