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Scientific Proceedings (129) 



glands. She was caged with male dogs for a year and never 

 became pregnant, but she is neither sluggish nor somnolent. 

 The remainder of the series are eliminated because when killed 

 for examination vestiges of hypophysis were found, or the dog 

 died of pneumonia or meningitis soon after operation. The dogs 

 with hypophysis remnants showed no symptoms of hypophyseal 

 deficiency. 



All the dogs (except No. 52) that died following the hypo- 

 physectomy operation, the cause of death was either meningitis 

 or pneumonia (probably aspiration pneumonia). These dogs 

 died within 3 to 10 days following the operation. 



1. Completely hypophysectomized dogs may live indefinitely 

 without showing any of the Frohlich syndrome. 



2. Some of the completely hypophysectomized dogs show 

 Frohlich's syndrome in varying degrees (retarded growth, 

 adiposity, somnolence, loss of sex urge). 



3. The fact that all completely hypophysectomized dogs do 

 not exhibit the Frohlich syndrome seems to indicate that the 

 hypophysis itself is not the only factor involved in this malady. 

 The obvious varying or uncontrollable additional factor is the 

 injury to the base of the brain in these operations. 



133 (2093) 



The auto-hemolysin of paroxysmal hemoglobinuria. 

 By GEORGE M. MACKENZIE. 



[From the Department of Medicine of the College of Physicians 

 and Surgeons of Columbia University, and the Presbyterian 

 Hospital, New York.] 



The essential characteristic of the condition known as par- 

 oxysmal hemoglobinuria is the occurrence, as a result of ex- 

 posure to cold, of hemoglobinaemia and hemoglobinuria, usually 

 accompanied by a chill and rise of temperature. In the blood 

 of these patients there is present an auto-hemolysin which is 

 readily demonstrated by the simple procedure well known as 

 the Landsteiner reaction. In its simplest form it consists simply 



