298 



Scientific Proceedings (129) 



DOG 2-1, MALE, WEIGHT 12.9 KILOS. 



Day. 



R. B. C. 



Hemoglobin 



Color 



millions. 



per cent. 



index. 



1 



5.40 



83 



0.77 



3 



5.20 



83 



0.80 



4 



3.80 



77 



1.01 



5 



3.60 



66 



0.92 



7 



2.30 



44 



0.96 



8 



2.20 



33 



0.75 



10 



0.92 



28 



x.52 



11 



1.05 



25 



1.19 



Remarks 



Administered subcutaneously 

 0.258 grams symmetrical com- 

 pound. 



Marked lipemia. 



Dog very sick. 



Dog somewhat improved. 



Dog much improved; 0.120 

 gram of compound adminis- 

 tered. 



Dog received 0.240 grams of 

 compound. 



As in the case of phenylhydrazine, the isopropyl derivative 

 produces hypertrophy of the spleen and very marked hyper- 

 plasia of the bone marrow. Symmetrical di-isopropyl-hydrazine 

 also resembles hydrazine in its effect upon the liver; 2, 3 fatty de- 

 generation being produced after the administration of relative- 

 ly small doses. 



146 (2106) 



Further studies of the relative rates of absorption of drugs from 

 the lymph sac and the muscles of the frog. 



By C. D. HIGLEY and M. S. DOOLEY. 



[From the Syracuse University Medical School, Syracuse, 

 New York.] 



Previously it has been shown that members of the digitalis 

 group as measured by their intensity of action upon the heart, 

 are absorbed more rapidly and evenly from intramuscular in- 

 jections than from the lymph sac. Strychnine was also found 

 to be more rapidly absorbed from the muscles. These facts led 

 us to suggest that in the official assay of the digitalis group of 

 drugs the substitution of intramuscular injections be made. The 

 present paper deals with further studies of this question. 



2 Underbill, F. P., and Kleiner, I. S., J. Biol. Chem., 1908, iv, 165. 



3 Wells, H. G., J. Exp. Med., 1908, x, 457. 



