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Scientific Proceedings (130) 



at intervals during 4 to 6 hours after subcutaneous injection of 

 insulin. The blood sugar followed the course described by 

 Macleod and his collaborators in normal rabbits, falling from 

 initial values of 0.10 to 0.11 per cent, to a minimum of 0.039 to 

 0.048 per cent. (Folin-Wu method). When convulsions occur- 

 red, or the animal became comatose without going into convul- 

 sions subcutaneous injection of dextrose had the same markedly 

 beneficial effect as in the normal control animals. Usually there 

 was some rise in the rectal temperature (as much as 1.5° C. in a 

 case where the animal became comatose without convulsions, 

 and 2° C. in a case where convulsions occurred and dextrose was 

 injected). 



If the internal secretion of the pancreas and the internal se- 

 cretion of adrenal medulla both take a share in the regulation 

 of the blood sugar content (perhaps, as some have supposed, 

 by exerting actions more or less antagnostic) it might appear 

 not unlikely that each would influence the secretion of the 

 other. We have accordingly made some experiments on the 

 influence of insulin upon the output of epinephrin in the cat, in 

 which animal the blood sugar curve after insulin runs much the 

 same course as in the rabbit. Neither with subcutaneous nor 

 with intravenous injection of insulin was any decided effect pro- 

 duced upon the output. 



As evidence in favor of a relationship between the adrenals 

 and the pancreas, it has been stated that after removal of the 

 adrenals complete pancreatectomy does not produce hypergly- 

 cemia. This statement is based upon observations made on 

 practically moribund animals. Dogs after complete pancreatec- 

 tomy without interference with the adrenals show a hypoglycemia 

 some time before death. Certainly the epinephrin from the ad- 

 renals has nothing to do with the development of hyperglycemia 

 after pancreatectomy. The right adrenal was excised and the 

 left denervated in a dog, and a month later total pancreatectomy 

 was performed. The animal showed the typical picture of pan- 

 creatic diabetes, with blood sugar as high as 0.29 per cent. Two 

 weeks after the pancreatectomy the left adrenal was removed. 

 A few hours before this operation the blood sugar was 0.286 

 per cent. ; 18^ hours after the operation it was 0.288 per cent; 

 7 hours later 0.216 per cent. Two days after the operation it 

 was only 0.08 per cent, and next day the animal was dead. In 



