Iletin and Blood Sugar After Adrenalectomy 341 



this animal, 3 days after removal of the pancreas an experiment 

 was made to determine whether insulin would affect the blood 

 sugar content in the ordinary way in a dog whose epinephrin 

 secretion was suppressed. The course of the blood sugar curve 

 under the influence of insulin was the same as in a pancreatec- 

 tomized animal not subjected to the adrenal operation (initial 

 blood sugar 0.227; minimum reached in hours 0.063 per 

 cent.). 



165 (2125) 



The influence of iletin (insulin) on morphine hyperglycemia. 

 By G. N. STEWART and J. M. ROGOFF. 



[From the H. K. Cushing Laboratory of Experimental Medicine, 

 Western Reserve University.] 



It has been shown by Macleod and his collaborators that in- 

 sulin prevents the development of the hyperglycemia caused by 

 etherization, asphyxia, carbon monoxide and piqure, or counter- 

 acts it if already present. We have demonstrated that while 

 these forms of experimental hyperglycemia are not essentially 

 related to the adrenals, since they can be well elicited in the ab- 

 sence of those glands, this is not the case with the hyperglycemia 

 produced by morphine in the development of which the adrenals 

 seem to intervene in some way. We have therefore tested the 

 influence of insulin upon morphine hyperglycemia in rabbits and 

 cats. Whether morphine was given before, after, or at the same 

 time as insulin, the characteristic effect of insulin upon the blood 

 sugar was always observed. Thus, in a rabbit to which morhpine 

 was administered 1 hour before insulin the blood sugar, which 

 was 0.083 per cent, at the beginning of the experiment and 0.093 

 an hour after morphine, was 0.047 per cent, an hour after insulin 

 had been injected. The morphine hyperglycemia had not had 

 time to develop before insulin was given, nor did it develop in 

 the 6 hours over which blood samples were collected. In an- 

 other rabbit morphine was given an hour after insulin when the 

 blood sugar had already fallen from 0.115 to 0.068 per cent. 



