360 



Scientific Proceedings (131) 



CONCLUSIONS 



The results obtained above indicate that the extent of the 

 toxemia is related to the level of the non-protein rather than 

 the urea nitrogen. The toxemia is dependent upon the location 

 of the obstruction in relation to the duodenum and the type of 

 the obstruction, whether simple or segmental. From the prac- 

 tical standpoint the chemical examination of the blood is of 

 inestimable value in pre-operative diagnosis and prognosis. 



174 (2134) 



Cystine metabolism. 

 By G. J. SHIPLE, A. R. ROSE and C. P. SHERWIN. 



[From Fordham University, New York City.] 



In our study of cystine and cystein we have had in mind four 

 different problems. 



1. An attempt to synthesize cystine in the animal body either 

 from endogenous nitrogen and sulfur or from these same ele- 

 ments when fed in different forms. This could not be accom- 

 plished as has already been shown. 1 



2. We prepared several compounds of cystine and cystein 2 

 where first, the amino group was blocked by some radical such 

 as the phenylacetyl or phenyluramino, — then both the amino 

 group and the carboxyl as in the phenylhydantoin derivative, — 

 then a blocking of the S group with a benzyl radical followed 

 by a blocking of both S-H and amino group, and lastly a block- 

 ing of these two and the carboxyl group. 



3. We have fed these compounds in order to determine 

 whether the blocking of one or more of these groups prevent 

 the oxidation of the cystine or cystein molecule. Besides this we 



1 Muldoon, J. A., Shiple, G. J., and Sherwin, C. P., Proc. Soc. Exp. Biol, 

 and Med., 1922, xx, 4G. 



2 Shiple, G. J., and Sherwin, C. P. (in press), J. Biol. Chem., 1923, 

 lv, 671. 



