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Scientific Proceedings (131) 



183 (2143) 



Indican as influenced by bacillus acidophilus therapy. 

 By LILLIAN SEGAL KOPELOFF and NICHOLAS KOPELOFF. 



[From the Psychiatric Institute, Ward's Island, N. Y.] 



Over 150 urinanalyses were made on 40 psychotic patients. 

 The number of daily bowel movements were recorded, and 

 showed a range varying from normal to severe chronic consti- 

 pation. Various experimental procedures with B. acidophilus 

 were employed. Such an investigation must be continued for a 

 considerable period of time before any conclusions can be drawn. 

 However, in reporting progress, it is interesting to note that in 

 only five instances did the indican present exceed 20 mg. which 

 is generally regarded as the upper limit of normal excretion. 

 Some of the patients with severest constipation had very small 

 amounts of indican present in the urine. In general patients who 

 received B. acidophilus milk had a smaller amount of urinary 

 indican than patients receiving B. acidophilus milk in which the 

 viable organism had been killed. 



184 (2144) 



Leucocytes in relation to the mechanism of thyroid-accelerated 

 metamorphosis in the larval frog. 



By H. E. JORDAN and C. C. SPEIDEL. 



[From the Department of Histology and Embryology, University 

 of Virginia Medical School University, Virginia.] 



In the larval frog the chief locus of blood-cell formation is 

 the kidney. The intertubular regions of this organ are filled 

 with many erythrocytes and leukocytes in various stages of de- 

 velopment. The spleen and, to a less extent, the mesentery are 

 also hemopoietically active, but are of minor importance. In 

 the adult frog, however, conditions are different. The spleen is 



