390 



Scientific Proceedings (131) 



No; for one outstanding fact is that two healthy brothers may 

 differ at the same age, one being slender, the other very fleshy. 

 Different human strains differ in build just as Jersey steers differ 

 from Aberdeen Angus steers. Armsby has inquired into the 

 cause of the difference in build of such steers : he concluded that 

 it is partly due to different amounts of food consumed; the Jersey 

 steer is a lighter eater. It is also due to the fact that the Jersey's 

 excess calories are used in building up protein which stores up 

 a relatively great amount of energy, per kilogram, while in the 

 Angus, the excess calories are stored in the form of fat which 

 uses up relatively little energy per kilo. There is a difference 

 in the method of metabolizing. Apparently this difference is 

 found also in families, — so that we have some families in which 

 the members store fat, in others, protein; at least, some fatten 

 easily, others with difficulty. Probably the constitutional dif- 

 ference in human families is that which distinguishes chow dogs 

 and grey hounds, Cochin china pigs and razor backs. 



Returning to humans, one finds that the offspring of two very 

 slender parents are practically all slender. But the progeny of 

 two parents of medium build in certain cases range from very 

 slender to very fleshy. Slenderness is recessive; but fleshiness 

 is not differentiated genetically from slenderness by a single 

 factor, but sometimes by at least two independent factors, pos- 

 sibly more. However this may be, the analysis that can be ap- 

 plied to the 500 matings studied, shows that the capacity of fat- 

 tening easily depends on germinal factors just as truly as stature 

 does. 



189 (2149) 



The action of salicylates on the isolated heart. 



By WILLIAM SALANT and ROBERT L. JOHNSON. 

 (With the assistance of MISS SALLIE RUTLEDGE). 



[From the Laboratory of the Department of Physiology and Phar- 

 macology, University of Georgia, Augusta, Georgia.] 



Most of the experiments were carried out on the frog heart 

 but turtles were also used occasionally. Sodium salicylate in 

 different concentrations in Ringer's solution produced the fol- 

 lowing results : 



