400 



Scientific Proceedings (131) 



Recent experiments have shown that the amount of antitoxin 

 necessary to neutralize 10 M. L. D. of our toxin is slightly less 

 than 0.01 U. S. units. Since the tests for antitoxin in the serum 

 were made with only 0.1 c.c. this means that two of the babies 

 were born with approximately 0.25 units, one with 0.1 units, 

 two with 0.05 units and one with no appreciable antitoxin per 

 c.c. of serum. Although we have been unable to study the colos- 

 trum we should expect to find antitoxin there whenever we find 

 it in the serum, thus giving the child an additional supply. 



Since the antitoxin level in the mother's and child's bloods is, 

 in the majority of cases, at approximately the same level it seems 

 probably that the placenta is permeable to this antibody. It in- 

 dicates also that antitoxin has a much simpler structure than the 

 other so-called immune bodies which fail to pass this organ. 



195 (2155) 



The occurrence of intranuclear inclusion bodies in certain tissues 

 of the rabbit inoculated directly with the virus of herpes labialis. 



By ERNEST W. GOODPASTURE and OSCAR TEAGUE. 



[From the William H. Singer Memorial Research Laboratory, 

 Allegheny General Hospital, Pittsburgh, Pa.] 



B. Lipschiitz has described in experimental herpetic keratitis 

 of rabbits intranuclear, acidophilic bodies, staining readily with 

 eosin, variable in size and shape* but usually round or oval and 

 separated from the nuclear membrane by a narrow clear space. 

 They may appear homogeneous or faintly granular. He found 

 these bodies constantly in the nuclei of the epithelial cells and 

 considered them pathognomonic of this lesion. Rarely similar 

 bodies were encountered in the nuclei of connective tissue cells 

 of the lesion. He succeeded in demonstrating these bodies also 

 in the conjunctiva of the inoculated rabbit's eye and in herpetic 

 vesicles of human skin. 



We have attempted to determine in what tissues of the rabbit 

 the virus of herpes labialis will take as determined by the pres- 

 ence of the above intranuclear bodies at or near the sit of inoc- 



