402 



Scientific Proceedings (131) 



Abstracts of Communications. 

 Minnesota Branch. 



Eleventh meeting. 



Minneapolis, Minnesota, April 11, 1923. 



196 (2156) 



The antiseptic action of ethoxyquinolin, chitenin and H-acid. 



By A. D. HIRSCHFELDER, HERMAN H. JENSEN and V/. W. SWANSON. 



[From the Department of Pharmacology, University of 

 Minnesota.*] 



In 1911 Morgenroth and his collaborators 1 found that when 

 hydrocuprein, a quinine derivative, was changed to ethyl hydro- 

 cuprein the substance acquired specific pneumococcicidal powers, 

 both in vitro and in vivo. However, many clinicians have found 

 that in the treatment of lobar pneumonia ethyl hydrocuprein is 

 too toxic and that changes in the optic nerve and sometimes 

 permanent blindness may result from its use. 



Two years ago Pankow and Hirschfelder 2 investigated two 

 parallel series of simple aromatic substances, hydroxy com- 

 pounds and the corresponding ethoxy compounds, in order to 

 determine whether in these simple compounds also, the intro- 

 duction of an ethoxy group would yield increased pneumococci- 

 cidal action. The experiments showed, however, that this is not 

 the case. In the series reported in this paper we have tested 

 the action of 8-oxyquinolin sulphate 



OH 



/\ N 

 / \/ \ 



and 8-ethoxyquinolin sulphate 



OC 2 H 5 

 /\ N 



/ 



\/ 



\ 



\ 



)\ 



1 



* This research has been performed with the aid of funds from the re- 

 search fund granted the Graduate School by the Board of Eegents of the 

 University of Minnesota. 



1 Morgenroth, J., and collaborators, Berl. Klin. 1911, lxxi, 501; Ibid. 

 Ztschr. f. Immunitatsforchung, etc., 1912, xv, 610; 1920, xxix, 217. 



2 Hirschfelder, A. D., and Pankow, L. J., Proc. Soc. Exper. Biol, and 

 Med., N. Y., 1922, xix, 64. 



