438 



Scientific Proceedings (132) 



Ca 3 (P0 4 ) 2 Mg 3 (P0 4 ) 2 



Amount 





Phenol- 







Phenol- 





grams. 



Toepfer. 



plithalein. 



Ph 



Toepfer. 



phthalein. 



Ph 



0.100 



44.2 



55.4 



1.30 



45.0 



50.6 



1.40 



0.200 



36.4 



55.2 



1.60 



35.0 



45.5 



1.70 



0.400 



30.5 



54.8 



1.80 



15.4 



37.5 



2.30 



1.000 



9.2 



52.6 



2.60 



—9.1 



23.5 



6.0 



4.000 



2.3 



51.3 



3.30 



—16.0 



6.0 



6.7 



NaHC0 3 



Amount 









Phenol- 





grams 



Toepfer 







phthalein 



Ph 



0.100 



44.8 







46.1 



1.43 



0.200 



32.6 







35.6 



1.51 



0.400 



7.8 







14.8 



1.95 



1.000 



—65.0 







—2.9 



8.4 



CaC0 3 



0.100 



36.2 







37.4 



1.45 



0.200 



16.4 







19.0 



1.65 



0.400 



—6.1 







0.4 



7.0 



1.000 



—7.6 







—0.4 



7.0 





0.100 



15.0 







14.3 



1.9 



0.200 



—2.4 







—0.4 



8.0 



0.500 



—4.3 







—2.3 



9.1 



Calcium phosphate is slightly constipating and magnesium 

 phosphate is slightly laxative. The tendency of the patient to 

 constipation or to diarrhea determines the nature of the com- 

 pound to be used. The dose required is from one to three grams. 



The use of calcium carbonate and of magnesium oxide prob- 

 ably tends to a slight alkanization of the system, the degree de- 

 pending upon the nature of the diet. As against CaC0 3 , the 

 use of the phosphate has the added advantage of avoiding belch- 

 ing and as against MgO, of avoiding alkalinization of the stom- 

 ach, for MgO may produce a reaction as alkaline as P H 9°. 



Bismuth subcarbonate and "neutralon" have comparatively 

 little power to neutralize hydrochloric acid in the concentration 

 found in the stomach. Their therapeutic action probably de- 

 pends upon other factors. 



Calcium and magnesium phosphates have been used by sev- 

 eral physicians for from a few months to more than two years, 

 with favorable results in most cases. Some patients do not ob- 

 tain relief. In these, it is probable that a systemic alkanization, 



