Gastric Antacids 



439 



the liberation of a large quantity of gas or some other effect is 

 required. 



I am indebted to Dr. John L. Kantor for his assistance in ob- 

 taining clinical material and for his careful observation of the 

 patients. He is preparing a clinical report. 



219 (2179) 



Factors involved in blood volume regulation. 

 By ALFRED CHANUTIN (by invitation). 



[From the Sheffield Laboratory of Physiological Chemistry, Yale 

 University, New Haven, Conn.] 



That the volume of the blood is not normally constant is shown 

 by distinct diurnal variations in this value as determined by the 

 hemoglobin percentage when the animal (dog) is in complete 

 muscular rest and unanesthetized. Administration of ether is 

 immediately followed by a decrease in the relative blood volume 

 which condition persists not only throughout the period of 

 anesthesia but for some time afterward. 



When isotonic saline is injected intraperitoneally the diluting 

 effect on the blood volume is not observed until several hours 

 later. The oral administration of saline dilutes the blood to a 

 greater degree in similar time than similar doses of water. As 

 might be expected, intravenous injection of saline show the most 

 pronounced degree of dilution. Usually, however, the normal 

 relative blood volume is attained after approximately two hours 

 following the intravenous injection (100 c.c. per Rg. body wt.). 

 At this time, when large volumes of fluid are unaccounted for, 

 neither the muscles nor the liver show a detectable increase in 

 fluid-not-blood. Renal activity is not essential for this prompt 

 adjustment of blood volume for the urine volume does not ac- 

 count for the "lost" fluid. 



