472 



Scientific Proceedings (132) 



normal condition. The tough but extensile nature of the pellicle 

 may be further demonstrated by inflating the cell with distilled 

 water injected through a micropipette. From a cell ruptured 

 under pressure the entire pellicle may be removed. In every 

 case recorded the nucleus came away with the pellicle. Injec- 

 tion of various solutions usually causes an immediate inflation 

 of the Amoeba, the fluid collecting in an area beneath the pellicle, 

 while the endoplasm contracts into an irregular mass containing 

 the nucleus. 



235 (2195) 



The reaction of the endocrine system of the rabbit to tumor 

 inoculation and the relation of this reaction to malignancy. 



By WADE H. BROWN and LOUISE PEARCE. 



[From the Laboratories of the Rockefeller Institute for Medical 

 Research, New York, N. Y.] 



Within recent years, a great deal of evidence has been accu- 

 mulated from both clinical and laboratory sources which has 

 tended to show that some kind of connection exists between the 

 occurrence and growth of tumors and the system of organs regu- 

 lating animal economy. For the most part, the evidence bearing 

 upon this problem has been circumstantial. In a few instances 

 a definite relationship appears to have been established as in the 

 case of the experiments reported by Loeb 1 concerning the effects 

 of castration on the incidence of mammary tumors in mice and 

 those of Rohdenburg, Bullock, and Johnson 2 on the effects of 

 operative removal of various organs upon the growth of trans- 

 planted tumors and the immunity of tumor animals. There are 

 also therapeutic observations on the use of thyroid and of thymic 

 products alone or combined with castration 3 which might be 

 regarded as equally suggestive were it not for the fact that sim- 

 ilar results have been obtained by the use of a variety of means. 4 



1 Loci), L., J. Med. Res., 1919, xxxv, 447. 



2 Rohdenburg, G. L., Bullock, F. D., and Johnson, P. F., in Studies ill 

 Cancer (George Crocker Research Fund), 1913, iii, 87. 



8 Beatson, G. T., Glasgow Med. J., 1913, n. s. lxxvi, 81, and earlier reports. 

 4 A more recent article on this subject has been published by Enge in the 

 Ztschr. f. Krebsforsch., 1923, xix, 339. 



