Pulmonary Circulation' 



485 



Effect of Epinephrin: In spite of a cardiac acceleration, pro- 

 duced by the injection of 1-3 c.c. of a 1 :50,000 epinephrin solu- 

 tion, a definite decrease in the size of the visible pre-arterioles 

 and arterioles is noted. At times this amounts to a complete 

 cessation of flow in certain vessels. This supplies visible cor- 

 roborative evidence that epinephrin effects the smaller pulmon- 

 ary vessels. 



239 (2199) 



The respiratory exchange and blood sugar curves of normal and 

 diabetic subjects after epinephrin and insulin. 



By RICHARD S. LYMAN, ELIZABETH NICHOLLS and W. S. McCANN. 



[From the Chemical Division, Medical Clinic, Johns Hopkins 

 Hospital, Baltimore, Md.] 



This communication is based on a series of experiments con- 

 ducted on 5 normal men and 8 diabetics. The method of deter- 

 mining the respiratory exchange was carried out by the open- 

 circuit Tissot spirometer, with gas analyses by a modified Hen- 

 derson-Haldane apparatus and calculations of the indirect 

 calorimetry by the method of Zuntz and Schumburg, as recently 

 described by McCann and Hannon. 1 At varying intervals dur- 

 ing the experiments samples of blood were taken and blood- 

 sugar determinations were made according to the method of 

 Folin and Wu. 2 Coincident pulse and blood pressure charts 

 were also kept in most instances. 



The 5 normal men showed a similar reaction to 0.5 c.c. adren- 

 alin given subcutaneously. There was a prompt rise of the 

 R. O., which was most marked about 10 minutes after the 

 adrenalin. The quotient rose to a different extent, varying with 

 the individual. A distinct increase of heat-production occurred 

 with its maximum degree about 30 minutes after injection, re- 

 maining above the basal figure for over an hour. There ap- 

 peared an immediate and marked rise in carbohydrate metabolism 



1 McCann and Hannon, Johns Hopkins Hospital Bull., March, 1923, 

 xxiv, 73. 



2 Folin and Wu. Jour. Biol Chevi., 1920, xli, 3G7. 



