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Scientific Proceedings (132) 



with its maximum about 10 minutes after the adrenalin, as calcu- 

 lated from the non-protein R. O. Coincident alveolar air 

 analyses in one case indicated that overventilation may play a 

 role in the production of the higher respiratory quotients. 

 An elevation of blood-sugar followed the injection of adrenalin 

 reaching a maximum in 40-50 minutes after administration. It 

 was the most constant of any of the observed effects of the drug. 

 The sugar remained above normal limits for over \y 2 hours. 

 The pulse rate and blood pressure responded differently in dif- 

 ferent individuals. 



The reaction to adrenalin of the diabetic patients differed 

 in some respects from that in the control cases. Its appearance 

 was the more delayed, the sicker the patient. The R. O. did 

 not rise nearly as high as in the controls. There was only one 

 diabetic patient whose R. O. went up as many points as the 

 minimum control. After adrenalin the eight diabetic subjects 

 fell into two groups as regards the total heat production : — four 

 showing an increase from 6 to 18 per cent., the rest ranging 

 from 29 to 43 per cent, above normal. The equivalent figures 

 for the five normal cases lay between 17 and 33 per cent, above 

 the basal heat production. The blood-sugar did not rise as high 

 nor as quickly as in the controls, with one exception. The 

 change was very slow in some cases. The blood-sugar fell in 

 one case, which was repeated with identical result. 



The insulin reaction in normal subjects was observed in five 

 experiments in all, only two, however, having complete data. 

 Three and one-half units were usually given intravenously. 

 That dosage brought out a moderate reaction. Two and one- 

 half units caused a very slight reaction and five units required 

 the subsequent administration of sugar to relieve the symptoms 

 of hypoglycemia. The general course was similar in all experi- 

 ments of this group. There was a marked rise of R. O., com- 

 ing to a maximum about 30 minutes after the injection of insulin 

 An increase of heat production occurred, reaching its highest 

 point later than the maximum R. O., but returning to about 

 normal by two hours after the injection. There was a rapid fall 

 of blood-sugar which was at its lowest level from 20 to 30 

 minutes after insulin. By 40 minutes after a dose of 3 J / 2 units the 

 blood-sugar was already beginning to rise, and by 2 l / 2 hours 

 it had returned to about the normal figure. The diastolic blood 

 pressure usually fell. The systolic pressure rose 10 to 16 mm. 



