508 



Scientific Proceedings (132) 



each rat thrived normally until about the 15th to 21st day when 

 the young began to exhibit weakness, with spasms, and were de- 

 stroyed by their mothers. In the case of the second litter this 

 result was prevented by giving one mother 0.2 gram of dry 

 whole yeast daily and the other mother 0.2 gram of dry alfalfa 

 meal in the form of a pellet. Five of these second generation 

 rats, representing both litters, are at present doing well on the 

 "artificial" milk," without the additions mentioned. 



It is not possible, at present, to reconcile the results of this 

 experiment with those of Mattill or with our own on whole 

 milk. There seems to be evidence that milk only as the sole diet 

 lacks something for the attainment of normal sexual maturity in 

 the female rat. Our results might also be interpreted to indicate 

 a lack of something required for normal lactation, were it not 

 for extensive unpublished data which we have showing that the 

 addition of 10 c.c. of whole milk (1.25 grams of milk solids) 

 to the diet of rats which fail to grow normally, as well as repro- 

 duce, has resulted in the securing of normal rats in experiments 

 which have, to date, reached the third generation. 



251 (2211) 



The effect of local anaesthetics upon the conjunctivitis caused 



by mustard oil. 



By ARTHUR D. HIRSCHFELDER. 



[From the Department of Pharmacology, University of Minnesota, 

 Minneapolis, Minnesota*} 



Spiess 1 and Ninian Bruce 2 have shown that the oedema of the 

 conjunctiva which can be produced by instilling mustard oil into 

 the conjunctival sac of a rabbit, can be prevented by the instilla- 

 tion of 10 per cent, cocaine. Bruce interprets this action as being 

 due to the inhibition of vasdilator axon reflexes to the capillaries 



* I desire to express my thanks to Messrs. K. Hultkrans, H. Webber and 

 J. May for their assistance in carrying out these experiments. 



1 Spiess, G., Muenchen Med. Woch., 1906, 345. 



2 Bruce, A. Ninian, Arch. f. Exper. Path. u. Pharmacol., 1910, lxiii, 424. 



