516 Scientific Proceedings (132) 



Abstracts of Communications. 

 Seventh meeting. 



Western New York Branch. 

 Ithaca, New York, May 12, 1923. 



255 (2215) 



The effect of thyroid gland from young calf upon the blood 

 sugar in depancreatized dogs. 



By G. A. FRIEDMAN. 



[From the Department of Clinical Pathology, College of Physicians 

 and Surgeons, Columbia 'University.'] 



Every clinician must have observed from time to time the 

 appearance of sugar in the urine after prolonged use of thyroid 

 extract in patients. 



Magnus-Levy 1 writes that glycosuria may be noted from large 

 dosages of thyroid in man as well as in dogs. Since glycosuria 

 may occur as a result of thyroid feeding, it was thought that the 

 high percentage of iodine in the gland of the ox might be the 

 determining factor in the appearance of sugar in the urine after 

 prolonged use of the drug. 



According to Hammarsten 2 the thyroid of man contains 0.34 

 per cent, iodine ; the thyroid of ox contains 0.86 per cent. It was 

 thought that thyroid which is iodine free must have the reverse 

 effect on the blood-sugar contents. It is a well established fact 

 that the thyroid of newborn animals does not contain iodine. 

 Thyroids from such calves were procured from the slaughter 

 house immediately after killing and extracts from the weighed 

 glands prepared. The alcoholic extracts in Ringers solution 

 were injected intravenously or subcutaneously* or administered 

 by the stomach tube to dogs. The extracts were prepared in the 

 same manner as the pancreatic extracts by Banting and Best. 



1 Magnus-Levy, Kraus und Brugsch, Specielle Pathol, u. Therapie, 1919, 



i, 8. 



2 Hammarsten, " Physiological Chemistry," 1909, Fifth Edition. John 

 Wiley and Sons, New York. English translation by John A. Mandel. 



