Blood Sugar 



517 



After weighing the thyroids they were cut in very small pieces 

 and placed in 0.2 per cent. HC1 in 95 per cent, alcohol and 

 allowed to stand for two days. They were then macerated with 

 quartz and filtered, or when using large amounts first macerated 

 and then put in a press and filtered. The clear filtrate was 

 evaporated to dryness in a warm air current. On the next day 

 or on the third day the dry residue was emulsified with 25 c.c. 

 Ringers solution. 25 c.c. of this solution contained the thyroid 

 residue from 10, 20 or 50 grams gland. 



The blood-sugar was determined before injection or oral ad- 

 ministration and two or three hours later. The dogs were 

 starved at least 24 hours before the experiments. For one ex- 

 periment a normal dog was injected first with calf's pancreas 

 prepared by the same method. 



January 3, 1923 



January 8, 1923 



January S, 1923 



January 26, 1923 



January 26, 1923 



Control — 

 January 28, 1923 



January 10, 1923 

 January 12, 1923 



January 13, 1923 



March 10. 1923 



January 31, 1923 

 February 15, 1923 



Februarv 



1923 



Dog 168. Male. Weight, 8 kilos. 

 Bloodsugar 89 mg. in 100 c.c. 

 Bloodsugar 89 mg. 12 Iff. 



Bloodsugar 45 mg. 2 P. Iff. after injection of 5 c.c. 



residue from whole pancreas. 

 Bloodsugar 100 mg. 12 M. 



Bloodsugar 80 mg. 2 P. M. after intrayenous injec- 

 tion of 10 c.c. Ringers solution which contained a 

 residue from 8 grams thyroid gland. 



Bloodsugar 98 mg. 1:30 P. M. 



Bloodsugar 100 mg. 3:30 P. M. after intrayenous in- 

 jection of 10 c.c. Ringers solution per se. 



Dog 169. Male. Weight, 12.2 kilos. 



Partial pancreatectomy. Glycosuria absent. 

 Bloodsugar 133 mg: 2*P. M." 



Bloodsugar 123 mg. 4 P. M. after intrayenous in- 

 jection of 10 c.c. Ringers solution which contained 

 residue from 4 grams thyroid. 



Bloodsugar 128 mg. 2:15 P. M. 



Bloodsugar 117 mg. 4:15 P. M. after subcutaneous 

 injection of 10 c.c. Ringers solution which con- 

 tained residue from 4 grams thyroid. 



Dog 175. Male. Weight, 11.6 kilos. 

 Bloodsugar 80 mg. 12:30 P. M. 



Bloodsugar 71 mg. 3:30 P. M. after administration 

 through stomach tube of 10 c.c. Ringers solution 

 which contained residue from 4 grams thyroid 

 gland. 



Dog 171. Male. Weight, 19.8 kilos. 

 Total pancreatectomy. 



Incomplete thyroidectomy. Persistent intense glyco- 

 suria until March 7, when disposed of. 

 Bloodsugar 333 mg. 2:25 P. M. 



Bloodsugar 312 mg. 4:25 P. M. after oral admin- 

 istration of 10 c.c. Ringers solution which con- 

 tained residue from 8 grams thyroid. 



