518 



Scientific Proceedings (132) 



February 12, 1923 Bloodsugar 312 2:15 P. M. 



Bloodsugar 277 4:15 P. M. after oral administration 

 of 25 e.c. Eingers solution which contained residue 

 from 50 grams thyroid. 



Control— Bloodsugar 250 mg. 3:15 P. M. 



February 23, 1923 Bloodsugar 250 mg. 5:15 P. M. after oral administra- 

 tion of 25 c.c. Ringers solution per se. 



Dog 176. Male. Weight, 9 kilos. 

 March 22, 1923 Almost complete pancreatectomy. Persistent intense 



glycosuria. Dog was found dead April 3, 1923. 

 April 2, 1923 Bloodsugar 164 mg. 2 P. M. 



Bloodsugar 127 mg. 4 P. M. after oral administra- 

 tion of 25 c.c. Ringers solution containing residue 

 from 50 grams. 



Dog 167. Female. Weight, 7.4 kilos. 

 December 21, 1922 Pancreatic ducts were ligated and cut. 

 January 25, 1923 Bloodsugar 93 mg. 



Bloodsugar 89 mg. 1:30 P. M. 



Bloodsugar 71 mg. 3:30 P. M. after oral administra- 

 Jauuary 29, 1923 tion of 10 c.c. Ringers solution containing residue 



from 8 grams thyroid. 



These experiments tend to show that there is in the normal 

 as well as in the depancreatized dog a reduction in blood-sugar 

 after intravenous, subcutaneous or oral administration of thyroid 

 gland of young calf. It is evident from these experiments that 

 extracts prepared from larger amounts of thyroid were more 

 effective in reducing the blood-sugar contents than when pre- 

 pared from smaller amounts. It must be admitted that the ex- 

 periments are too few to draw any definite conclusions. The 

 fact that the thyroid gland from newborn calves has a marked 

 influence in lowering the blood-sugar contents in depancreatized 

 dogs when given by mouth, is important since the oral adminis- 

 tration of insulin has no effect on the blood-sugar contents. 



Further experiments along these lines are in progress. 



