522 



Scientific Proceedings (132) 



258 (2218) 



The free sugar in the liver and its significance for carbohydrate 



metabolism. 



By K. F. CORI, G. W. PUCHER, G. T. CORI. 



[From the State Institute for the Study of Malignant Disease, 



Buffalo, N. Y.] 



Curves were presented showing the influence of adrenaline 

 and iletin on the free sugar content of the liver and the blood- 

 sugar. Further curves showed the influence of glucose inges- 

 tion on the free sugar of the liver and the relation of free liver 

 sugar to glycogen synthesis w T ith and without iletin. These curves 

 show that the prolonged hyperglycemia after adrenaline injection 

 is due to the fact that the sugar set free in the liver during the first 

 hour diffuses into the blood stream very slowly. It was shown that 

 iletin lowered the free sugar of the liver even during glucose 

 absorption. Ingestion of glucose without iletin increases the 

 free liver sugar. Glycogen synthesis without the administration 

 of iletin has only been observed when the free liver sugar was 

 above its normal value. (Normal value for animals starved for 

 24 hours is 0.3-0.35 per cent.) Glycogen synthesis under the 

 action of iletin occurs from normal or even lower than normal 

 free sugar levels. This data indicates a disturbance of the fer- 

 ment equilibrium normally established in the liver and is one of 

 the factors involved in the lowering of the blood-sugar observed 

 after the injection of iletin. 



