24 



Scientific Proceedings (6i). 



is the increased resorption and deposition in acromegaly with 

 high P metabolism. Other less essential glands as the thymus 

 apparently act mainly as supplies and stores of nuclein. 



The importance of phosphoric acid for oxidation processes as 

 fermentation is readily correlated on this basis with disturbances 

 of carbohydrate oxidation (diabetes, decreased oxidation with 

 hypofunction and increased with hyperfunction of pituitary and 

 thyroid, and other well known examples). As indicated above, 

 as well as by tartrate production of nephritis, excretion by kidneys 

 and intestine as well as maintenance of blood neutrality are much 

 more than simple mass action and filtration processes. 



I 6 (948) 



The effect of lead on the germ cells of the male rabbit and fowl 

 as indicated by their progeny. 1 



By L. J. Cole and L. J. Bachhuber. 



[From the Department of Experimental Breeding, Wisconsin Agri- 

 cultural Experiment Station.] 



The experiments of Stockard 2 on guinea pigs and of Cole and 

 Davis 3 on rabbits have shown conclusively that alcohol has a 

 deleterious effect on the germ cells of the male. In the experi- 

 ments here reported lead, in the form of lead acetate, was substi- 

 tuted for the alcohol, lead being chosen because of its reputed 

 effect upon the offspring of workers, whether male or female, in 

 trades where they are exposed to lead in its various forms. The 

 method of double mating described by Cole and Davis was 

 employed. This consists in breeding a female of a certain type 

 to two males at the same period. The males are of such gametic 

 constitution that the young of each may be identified by color or 

 other characteristics. The experimental animals used were 



1 Papers from the Department of Experimental Breeding of the Wisconsin 

 Agricultural Experiment Station, No. 3. 



s See especially " The effect on the offspring of intoxicating the male parent 

 and the transmission of the defects to subsequent generations," Amer. Nat., Vol. 47, 

 No. 563, pp. 641-682, 1913. 



3 "The effect of alcohol on the male germ cells, studied by means of double 

 matings," Science (N. S.), Vol. 39, No. 1004, pp. 476-477, 1914- 



